Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage
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چکیده
منابع مشابه
Prevention of encrustation and blockage of urinary catheters by Proteus mirabilis via pH-triggered release of bacteriophage
The crystalline biofilms of Proteus mirabilis can seriously complicate the care of patients undergoing long-term indwelling urinary catheterisation. Expression of bacterial urease causes a significant increase in urinary pH, leading to the supersaturation and precipitation of struvite and apatite crystals. These crystals become lodged within the biofilm, resulting in the blockage of urine flow ...
متن کاملBacteriophage Can Prevent Encrustation and Blockage of Urinary Catheters by Proteus mirabilis.
Proteus mirabilis forms dense crystalline biofilms on catheter surfaces that occlude urine flow, leading to serious clinical complications in long-term catheterized patients, but there are presently no truly effective approaches to control catheter blockage by this organism. This study evaluated the potential for bacteriophage therapy to control P. mirabilis infection and prevent catheter block...
متن کاملControl of encrustation and blockage of Foley catheters.
Urinary catheters often become encrusted and blocked by crystalline Proteus mirabilis biofilms. Results of experiments in a laboratory model of a Foley catheterised bladder infected with P mirabilis showed that when retention balloons were inflated with a solution of triclosan (10 g/L), the catheters drained freely for at least 7 days. Triclosan became impregnated throughout the silicone cathet...
متن کاملBacteriophage typing of Proteus mirabilis, Proteus vulgaris, and Proteus morganii.
A bacteriphage typing scheme for differentiating Proteus isolated from clinical specimens was developed. Twenty-one distinct patterns of lysis were seen when 15 bacteriophages isolated on 8 Proteus mirabilis, 1 P. vulgaris, and 1 P. morganii were used to type 162 of 189 (85.7%) P. mirabilis and P. vulgaris isolates. Seven phages isolated on 3 P. morganii were used to type 13 of 19 (68.4%) P. mo...
متن کاملHow to manage encrustation and blockage of Foley catheters.
catheter changes based on individual patients’ patterns of blockage. In addition, catheter washouts with acidic catheter maintenance solutions (which are used to dissolve encrusted material) can be used to prolong the period that the catheter remains patent. However, although all catheters are susceptible to this problem, there are no effective procedures for preventing it (Morris et al, 1997)....
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ژورنال
عنوان ژورنال: Journal of Materials Chemistry B
سال: 2017
ISSN: 2050-750X,2050-7518
DOI: 10.1039/c7tb01302g